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Ask your pharmacist or check the Medication Guide for a list of the ingredients. If your child misses several doses of tacrolimus due to vomiting, surgery, inability to swallow, or other reasons, he or she can receive the medication intravenously. Serious infections. These growths can be internal or external, such as swollen glands in the neck, armpit, tonsil area, or groin. Kidney may be given within 24hrs of transplantation but should be delayed until renal function has recovered : initially 0. Your message has been successfully sent to your colleague. You should not breast-feed while you are using tacrolimus. Chemically it is a membered macrolide lactone that was first discovered in from the fermentation broth of a Japanese soil sample Ptograf contained the bacterium Streptomyces tsukubaensis. Do not save this mixture for later use. Ask your doctor or pharmacist if you do not understand these instructions. Tacrolimus weakens your Progeaf immune system, to help keep it from "rejecting" a transplanted organ such as a kidney. Do not open the immediate-release capsules, Your doctor will monitor you carefully and adjust your dose as needed. Your doctor will need to monitor your blood pressure carefully during your treatment. Introduction: The prevention of allograft rejection a foremost challenge for the clinicians involved in transplant. Stop taking tacrolimus and call your doctor right away if you have signs of infection such as: fever, chills, flu symptoms, cough, sweating, painful skin sores, skin warmth or redness, or muscle aches. Other uses for this medicine. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Keep from freezing. In submitting their manuscripts, the authors transfer, assign, and otherwise convey all copyright ownership to CSHP. If you are using the granule for oral suspension, you may take it with or without food, but you should take it the same way each time. Tacrolimus Dosage. Support the hospital by making a donation onlinejoining our Heroes in Healing monthly donor programor visiting our site to learn about the other ways you can give back. Legal Conditions and Terms Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Precautions for Children Your child should receive tacrolimus exactly as prescribed, at the same times each day. Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. Liver: initially 0. Mix the contents and then immediately take the mixture by mouth from the cup or with an oral syringe; do not save the mixture for a later time. Do not take more or less of it and do not take it more often than your doctor ordered. Be sure to tell your physician about all the drugs you take. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. In line with literature in patients receiving Advagraf displayed reduced lipid levels. Enter Zip Code GoodRx. FDA alerts for all medications. To make an appointmentplease call from 7 a. Tacrolimus Side Effects. Prograf with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression If this happens, wash your skin with soap and water or rinse your eyes with water. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. Astellas Pharma US, Inc. Q: Does Prograf cause an increase in appetite and weight gain? Advagraf 1 mg was dispensed with instructions for twice-daily dosing. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Actively involve patients and family members as applicable in the medication-use process. As mentioned, if two methoxymalonyl CoA molecules are substituted for two malonyl-CoA molecules, they will take place in module 7 and 8 C13 and C15and fkbA enzyme will enforce this process. Astellas Pharma Canada Inc is working to implement various measures to reduce the potential for mix-ups between Prograf and Advagraf. Add prominent descriptors for Prograf e. For example, if your child takes tacrolimus at a. Monitor and control BP. Top of Page. Wear protective clothing and use sunscreen Progrwf 30 or higher when you are outdoors. Archived from the original PDF on Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Daily news summary. I had a heart transplant in August Many other medications may also interact with tacrolimus, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Talk with your doctor about the risks and benefits of using this medicine. Toggle navigation. What should I avoid while taking tacrolimus? Popular Emailed Recent Loading The website you are linking to is not owned or controlled by Astellas. Alcohol can make the Prlgraf effects from tacrolimus worse. Consider an automated alert for computerized prescriber and pharmacy order entry systems that includes information such as the following:. Hepatic or renal impairment; PPrograf and consider dose reduction. If Progrsf extended-release tablet dose is missed, take the dose it if it is within 15 hours after missing the dose. This is more likely to occur with high doses; the symptoms should improve as the dose is reduced. Call your doctor right away if you have symptoms of a serious brain infection, such as a change in your mental state, problems with speech or walking, or decreased vision. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. Please enable scripts and reload this page. Concomitant corticosteroid is recommended early post-transplantation. Studies suggest that children generally tolerate tacrolimus well; they are less likely to suffer from hypertension or need steroid or insulin treatments. Mayo Clinic does not endorse any of the third party products and services advertised. Avoid sunlight or tanning beds. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Keep from freezing. What other drugs will affect tacrolimus? Hispanics and African Americans who've had kidney transplants are at an especially high risk. With m y CHP, you can request appointments, review test results, and more. Prograf drug interactions in more detail. This may increase the risk that you will get a serious infection. Obtain tacrolimus whole blood concentrations, serum creatinine, serum potassium, and fasting glucose periodically. Tacrolimus can be taken with or without food. Prograf may increase your risk of developing a serious infection, lymphoma, or other cancers. You might have to take this medicine for the rest of your life to prevent your body from rejecting the transplant. Drugs and Supplements Tacrolimus Oral Route. Try to space your doses about 12 hours apart, and take this medicine around the same time each day. Drug Class. Follow all directions on your prescription label and read all medication guides or instruction sheets. What happens if I miss a dose? It works by blocking the action of certain blood cells that can Profraf the body to reject a transplanted organ. Before Porgraf take PROGRAF, tell your healthcare provider about all of your medical conditions, including Prgraf you: Progeaf to receive any live vaccines people taking PROGRAF should not receive live vaccines have or have had liver, kidney or heart problems are pregnant or plan to become pregnant. Keep all appointments with your healthcare provider while taking this drug. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroidsmycophenolateand IL-2 receptor inhibitors such as basiliximab. Once two malonyl-CoA molecules are replaced, post-synthase tailoring steps are no longer required where two methoxymalonyl CoA molecules are substituted. Adult: Give at least 6hrs after transplantation. Dosages are titrated to target blood levels.
(Active Ingredient: Tacrolimus)
Prograf is used together with other medicines to prevent your body from rejecting a heart, liver, or kidney transplant.
Other names for this medication:
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    Prograf is used for preventing organ rejection in patients following liver, kidney, or heart transplant. It may be used along with other medicines. Prograf is an immunosuppressant. It blocks the action of certain blood cells (eg, T lymphocytes) that can cause the body to reject the transplanted organ.


    Use Prograf as directed by your doctor.

    • Do not take Prograf in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
    • Prograf is usually taken every 12 hours. Your doctor may occasionally change your dose to make sure you get the best results from this medication.
    • Prograf can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis.
    • Your kidney or liver function may also need to be tested.
    • Continue to use Prograf even if you feel well. Do not miss any dose. 
    • Grapefruit and grapefruit juice may increase the risk of side effects from Prograf. Talk to your doctor before including grapefruit or grapefruit juice in your diet while taking Prograf.
    • If you miss a dose of Prograf, contact your doctor right away.

    Ask your health care provider any questions you may have about how to use Prograf.


    Store Prograf at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Do not store in the bathroom. Keep Prograf out of the reach of children.


    Active Ingredient: Tacrolimus.

  • Do NOT use Prograf if:

    • you are allergic to any ingredient in Prograf, including castor oil
    • you are taking astemizole, cisapride, dofetilide, ibutilide, a potassium-sparing diuretic (eg, spironolactone), sirolimus, terfenadine, or ziprasidone
    • you have taken cyclosporine with the last 24 hours.

    Contact your doctor or health care provider right away if any of these apply to you.

    Some medical conditions may interact with Prograf. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

    • if you are pregnant, planning to become pregnant, or are breast-feeding
    • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
    • if you have allergies to medicines, foods, or other substances
    • if you have heart, kidney, or liver problems; diabetes; or high potassium levels in your blood.

    Some medicines may interact with Prograf. Tell your health care provider if you are taking any other medicines, especially any of the following:

    • Potassium-sparing diuretics (eg, spironolactone) because the risk of high blood potassium levels may be increased
    • Cyclosporine or other medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cisplatin, cyclosporine, ganciclovir, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], vancomycin) or the liver (eg, acetaminophen, methotrexate, ketoconazole, isoniazid, certain medicines for HIV infection) because the risk of kidney or liver side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney or liver
    • Many prescription and nonprescription medicines (eg, used for infections, inflammation, aches and pains, high blood pressure, high cholesterol, seizures, stomach problems), multivitamin products, herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort), astemizole, cisapride, dofetilide, ibutilide, sirolimus, terfenadine, and ziprasidone may interact with Prograf, increasing the risk of side effects.

    This may not be a complete list of all interactions that may occur. Ask your health care provider if Prograf may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

    Important safety information:

    • Prograf may cause drowsiness and dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Prograf with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
    • Do not change your dose of Prograf without first checking with your doctor.
    • Prograf may increase your risk for developing skin cancer. Avoid using sunlamps or tanning booths. Limit your exposure to the sun. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
    • Check with your doctor before you drink alcohol while you are taking Prograf.
    • Check with your doctor before you use a salt substitute or a product that has potassium in it.
    • Prograf may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
    • Prograf may increase the risk of certain infections, especially inactive viral infections, including BK virus associated nephropathy and JC virus-associated progressive multifocal leukoencephalopathy (PML). These infections can lead to serious, sometimes fatal, outcomes. Contact your doctor right away if you experience clumsiness, weakness on one side of the body, trouble speaking (eg, word-finding difficulty, slurred speech), or loss of vision.
    • Do not receive a live vaccine (eg, measles, mumps) while you are taking Prograf. Talk with your doctor before you receive any vaccine.
    • Patients who take Prograf after an organ transplant may have an increased risk for developing high blood sugar or diabetes. The risk is higher among black and Hispanic patients after a kidney transplant. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
    • Lab tests, including blood counts, blood potassium and glucose levels, kidney function, heart function, and blood pressure, may be performed while you use Prograf. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
    • Caution is advised when using Prograf in children; they may be more sensitive to its effects, especially lymphoma.
    • Pregnancy and breast-feeding: Prograf has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prograf while you are pregnant. Prograf is found in breast milk. Do not breastfeed while taking Prograf.
  • All medicines may cause side effects, but many people have no, or minor, side effects.

    Check with your doctor if any of these most common side effects persist or become bothersome:

    Back pain; constipation; diarrhea; dizziness; headache; joint pain; loss of appetite; nausea; stomach pain or upset; trouble sleeping; vomiting.

    Seek medical attention right away if any of these severe side effects occur:

    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; decreased coordination; chest pain; diabetes (frequent urination, increased thirst or hunger); fast or irregular heartbeat; fever, chills, or sore throat; mental or mood changes (eg, anxiety, confusion) one-sided weakness; painful urination or changes in the amount of urine; red, swollen, blistered, or peeling skin; seizures; severe or persistent dizziness or headache; shortness of breath; swelling of the hands, feet, or legs; tingling or numbness in the hands or feet; tremor; trouble speaking; unusual bruising or bleeding; unusual lumps or skin lesions; unusual weakness or tiredness; vision changes; yellowing of the skin or eyes.

    This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.